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Dokumenttyp:
journal article 
Autor(en):
Kim, Seonil; Titcombe, Roseann F; Zhang, Hong; Khatri, Latika; Girma, Hiwot K; Hofmann, Franz; Arancio, Ottavio; Ziff, Edward B 
Titel:
Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. 
Abstract:
Gene knockout (KO) does not always result in phenotypic changes, possibly due to mechanisms of functional compensation. We have studied mice lacking cGMP-dependent kinase II (cGKII), which phosphorylates GluA1, a subunit of AMPA receptors (AMPARs), and promotes hippocampal long-term potentiation (LTP) through AMPAR trafficking. Acute cGKII inhibition significantly reduces LTP, whereas cGKII KO mice show no LTP impairment. Significantly, the closely related kinase, cGKI, does not compensate for c...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2015 
Band / Volume:
112 
Heft / Issue:
10 
Seitenangaben Beitrag:
3122-7 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie