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Document type:
journal article 
Author(s):
Ebbers, Lena; Satheesh, Somisetty V; Janz, Katrin; Rüttiger, Lukas; Blosa, Maren; Hofmann, Franz; Morawski, Markus; Griesemer, Désirée; Knipper, Marlies; Friauf, Eckhard; Nothwang, Hans Gerd 
Title:
L-type Calcium Channel Cav1.2 Is Required for Maintenance of Auditory Brainstem Nuclei. 
Abstract:
Cav1.2 and Cav1.3 are the major L-type voltage-gated Ca(2+) channels in the CNS. Yet, their individual in vivo functions are largely unknown. Both channel subunits are expressed in the auditory brainstem, where Cav1.3 is essential for proper maturation. Here, we investigated the role of Cav1.2 by targeted deletion in the mouse embryonic auditory brainstem. Similar to Cav1.3, loss of Cav1.2 resulted in a significant decrease in the volume and cell number of auditory nuclei. Contrary to the deleti...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2015 
Journal volume:
290 
Journal issue:
39 
Pages contribution:
23692-710 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Institut für Pharmakologie und Toxikologie