User: Guest  Login
Document type:
journal article 
Author(s):
Ahles, Andrea; Rodewald, Fabian; Rochais, Francesca; Bünemann, Moritz; Engelhardt, Stefan 
Title:
Interhelical interaction and receptor phosphorylation regulate the activation kinetics of different human ?1-adrenoceptor variants. 
Abstract:
G protein-coupled receptors represent the largest class of drug targets, but genetic variation within G protein-coupled receptors leads to variable drug responses and, thereby, compromises their therapeutic application. One of the most intensely studied examples is a hyperfunctional variant of the human ?1-adrenoceptor that carries an arginine at position 389 in helix 8 (Arg-389-ADRB1). However, the mechanism underlying the higher efficacy of the Arg-389 variant remained unclear to date. Despite...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2015 
Journal volume:
290 
Journal issue:
Pages contribution:
1760-9 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Institut für Pharmakologie und Toxikologie