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Original title:
Das Biosynthesenetzwerk indolischer Sekundärmetabolite in Arabidopsis thaliana 
Translated title:
The biosynthetic network of indolic secondary metabolites in Arabidopsis thaliana 
Year:
2018 
Document type:
Dissertation 
Institution:
Fakultät Wissenschaftszentrum Weihenstephan 
Advisor:
Glawischnig, Erich (Prof. Dr.) 
Referee:
Glawischnig, Erich (Prof. Dr.); Schwab, Wilfried (Prof. Dr.) 
Language:
de 
Subject group:
BIO Biowissenschaften 
Keywords:
Phytoalexin, Camalexin, Trp-Metabolismus, Biosynthesenetzwerk, Metabolitanalyse, Cytochrom P450, Indol-3-Carbonsäure, TALEN, genome editing, Gencluster 
Translated keywords:
phytoalexin, camalexin, Trp metabolism, biosynthesis network, metabolic analysis, cytochrome P450, indole-3-carboxylic acid, TALEN, genome editing, gene cluster 
TUM classification:
BIO 400d 
Abstract:
Zur Abwehr von Schadorganismen produzieren Brassicaceae eine Reihe bioaktiver Sekundärmetabolite. Dabei ist die Biosynthese des Phytoalexins Camalexin chemisch eng mit der Synthese anderer Indolverbindungen verknüpft. Metabolitanalysen von mittels genome editing generierten Mehrfachmutanten beleuchten die Rolle mehrerer Cytochrom P450 abhängiger Monooxygenasen (CYPs), darunter die Homologe CYP71A12 und CYP71A13, CYP71B6, sowie einer Aldehydoxidase, in diesem Netzwerk. 
Translated abstract:
As part of their defence strategy, Brassicaceae produce a variety of bioactive secondary metabolites. The biosynthesis of the phytoalexin camalexin is strongly interconnected with the synthesis of other indolics. Metabolic analysis of multiple mutants that were generated applying targeted genome editing techniques elucidates the role of one aldehyde oxidase and several cytochromes P450, including CYP71B6 and the homologues CYP71A12 and CYP71A13, in this network. 
Oral examination:
07.12.2018 
File size:
7010037 bytes 
Pages:
172 
Last change:
07.12.2019