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Document type:
Zeitschriftenaufsatz 
Author(s):
5) Judson RN, Gray SR, Walker C, Carroll AM, Itzstein C, Lionikas AM, Zammit PS, Bari CD, Wackerhage H 
Title:
Constitutive expression of yes-associated protein (Yap) in adult skeletal muscle fibres induces muscle atrophy and myopathy 
Abstract:
The aim of this study was to investigate the function of the Hippo pathway member Yes-associated protein (Yap, gene name Yap1) in skeletal muscle fibres in vivo. Specifically we bred an inducible, skeletal muscle fibre-specific knock-in mouse model (MCK-tTA-hYAP1 S127A) to test whether the over expression of constitutively active Yap (hYAP1 S127A) is sufficient to drive muscle hypertrophy or stimulate changes in fibre type composition. Unexpectedly, after 5-7 weeks of constitutive hYAP1 S127A ov...    »
 
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit 
Journal title:
Plos One 
Year:
2013 
Journal volume:
Journal issue:
Pages contribution:
e59622 
Reviewed:
ja 
Language:
en 
E-ISSN:
1932-6203 
TUM Institution:
Sportbiologie