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Document type:
Zeitschriftenaufsatz 
Author(s):
Tremblay AM, Missiaglia E, Galli GG, Hettmer S, Urcia R, Carrara M, Judson RN, Thway K, Nadal G, Selfe JL, Murray G, Calogero RA, De Bari C, Zammit PS, Delorenzi M, Wagers AJ, Shipley J, Wackerhage H, Camargo FD 
Title:
The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation 
Abstract:
The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here we report that YAP1 activity is elevated in human embryonal rhabdomyosarcoma (ERMS). In mice, sustained YAP1 hyperactivity in activated, but not quiescent, satellite cells induces ERMS with high penetrance and short latency. Via its transcriptional program with TEAD1, YAP1 directly regulates several major hallmarks of ERMS. YAP1-TEAD1 upregulate pro-proliferative and oncogenic genes and maintain the ERMS...    »
 
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit 
Journal title:
Cancer Cell 
Year:
2014 
Journal volume:
26 
Pages contribution:
273-287 
Reviewed:
ja 
Language:
en 
Print-ISSN:
1535-6108 
Impact Factor:
27.41 
TUM Institution:
Sportbiologie