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Dokumenttyp:
journal article 
Autor(en):
Allen, Richard P; Donelson, Nathan C; Jones, Byron C; Li, Yuqing; Manconi, Mauro; Rye, David B; Sanyal, Subhabrata; Winkelmann, Juliane 
Titel:
Animal models of RLS phenotypes. 
Abstract:
Restless legs syndrome (RLS) is a complex disorder that involves sensory and motor systems. The major pathophysiology of RLS is low iron concentration in the substantia nigra containing the cell bodies of dopamine neurons that project to the striatum, an area that is crucial for modulating movement. People who have RLS often present with normal iron values outside the brain; recent studies implicate several genes are involved in the syndrome. Like most complex diseases, animal models usually do...    »
 
Zeitschriftentitel:
Sleep Med 
Jahr:
2017 
Band / Volume:
31 
Seitenangaben Beitrag:
23-28 
Sprache:
eng 
Print-ISSN:
1389-9457 
TUM Einrichtung:
Lehrstuhl für Neurogenetik (Fr. Prof. Winkelmann)