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Dokumenttyp:
journal article 
Autor(en):
Cancer Genome Atlas Research Network. Electronic address: andrew_aguirre@dfci.harvard.edu; Cancer Genome Atlas Research Network; Raphael, Benjamin J; Hruban, Ralph H; Aguirre, Andrew J; Moffitt, Richard A; Yeh, Jen Jen; Stewart, Chip; Robertson, A Gordon; Cherniack, Andrew D; Gupta, Manaswi; Getz, Gad; Gabriel, Stacey B; Meyerson, Matthew; Cibulskis, Carrie; Fei, Suzanne S; Hinoue, Toshinori; Shen, Hui; Laird, Peter W; Ling, Shiyun; Lu, Yiling; Mills, Gordon B; Akbani, Rehan; Loher, Phillipe; Lo...    »
 
Titel:
Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma. 
Abstract:
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGF?R2, GNAS, RREB1, and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS, BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbore...    »
 
Zeitschriftentitel:
Cancer Cell 
Jahr:
2017 
Band / Volume:
32 
Heft / Issue:
Seitenangaben Beitrag:
185-203.e13 
Sprache:
eng 
Print-ISSN:
1535-6108 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie