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Dokumenttyp:
journal article 
Autor(en):
Liu, Ya; Jolly, Claude; Braun, Susanne; Stark, Thomas; Scherer, Elias; Plontke, Stefan K; Kiefer, Jan 
Titel:
In vitro and in vivo pharmacokinetic study of a dexamethasone-releasing silicone for cochlear implants. 
Abstract:
Cochlear implants have been widely used for patients with profound hearing loss and partial deafness. Residual low-frequency hearing, however, may deteriorate due to insertion trauma and tissue response around the electrode array. The present study investigated in vitro and in vivo release of dexamethasone from silicone used for cochlear implant electrode carriers. The in vitro experiment involved an apparatus simulating the inner ear fluid environment in humans. Release from two sizes of silico...    »
 
Zeitschriftentitel:
Eur Arch Otorhinolaryngol 
Jahr:
2016 
Band / Volume:
273 
Heft / Issue:
Seitenangaben Beitrag:
1745-53 
Sprache:
eng 
Print-ISSN:
0937-4477 
TUM Einrichtung:
Hals-, Nasen-, Ohrenklinik und Poliklinik