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Document type:
Zeitschriftenaufsatz
Author(s):
Lehmann, Johannes; Richers, Johannes; Pöthig, Alexander; Sieber, Stephan A.
Title:
Synthesis of ramariolide natural products and discovery of their targets in mycobacteria
Abstract:
Ramariolides A-D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism.
Journal title:
Chemical communications (Cambridge, England)
Year:
2016
Journal volume:
53
Journal issue:
1
Pages contribution:
107-110
Fulltext / DOI:
doi:10.1039/c6cc08365j
Publisher:
Royal Society of Chemistry (RSC)
Print-ISSN:
1359-7345
E-ISSN:
1364-548X
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