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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Lehmann, Johannes; Richers, Johannes; Pöthig, Alexander; Sieber, Stephan A. 
Titel:
Synthesis of ramariolide natural products and discovery of their targets in mycobacteria 
Abstract:
Ramariolides A-D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism. 
Zeitschriftentitel:
Chemical communications (Cambridge, England) 
Jahr:
2016 
Band / Volume:
53 
Heft / Issue:
Seitenangaben Beitrag:
107-110 
Verlag / Institution:
Royal Society of Chemistry (RSC) 
Print-ISSN:
1359-7345 
E-ISSN:
1364-548X