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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Rosenberger, George; Liu, Yansheng; Röst, Hannes L; Ludwig, Christina; Buil, Alfonso; Bensimon, Ariel; Soste, Martin; Spector, Tim D; Dermitzakis, Emmanouil T; Collins, Ben C; Malmström, Lars; Aebersold, Ruedi 
Titel:
Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS 
Abstract:
Consistent detection and quantification of protein post-translational modifications (PTMs) across sample cohorts is a prerequisite for functional analysis of biological processes. Data-independent acquisition (DIA) is a bottom-up mass spectrometry approach that provides complete information on precursor and fragment ions. However, owing to the convoluted structure of DIA data sets, confident, systematic identification and quantification of peptidoforms has remained challenging. Here, we present...    »
 
Zeitschriftentitel:
Nature Biotechnology 
Jahr:
2017 
Verlag / Institution:
Springer Nature 
E-ISSN:
1087-01561546-1696 
Publikationsdatum:
12.06.2017