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Dokumenttyp:
journal article 
Autor(en):
Antyborzec, Inga; O'Leary, Valerie B; Dolly, James O; Ovsepian, Saak V 
Titel:
Low-Affinity Neurotrophin Receptor p75 Promotes the Transduction of Targeted Lentiviral Vectors to Cholinergic Neurons of Rat Basal Forebrain. 
Abstract:
Basal forebrain cholinergic neurons (BFCNs) are one of the most affected neuronal types in Alzheimer's disease (AD), with their extensive loss documented at late stages of the pathology. While discriminatory provision of neuroprotective agents and trophic factors to these cells is thought to be of substantial therapeutic potential, the intricate topography and structure of the forebrain cholinergic system imposes a major challenge. To overcome this, we took advantage of the physiological enrichm...    »
 
Zeitschriftentitel:
Neurotherapeutics 
Jahr:
2016 
Band / Volume:
13 
Heft / Issue:
Seitenangaben Beitrag:
859-870 
Sprache:
eng 
Print-ISSN:
1933-7213 
TUM Einrichtung:
Lehrstuhl für Biologische Bildgebung