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Document type:
journal article 
Author(s):
Aherrahrou, Zouhair; Schlossarek, Saskia; Stoelting, Stephanie; Klinger, Matthias; Geertz, Birgit; Weinberger, Florian; Kessler, Thorsten; Aherrahrou, Redouane; Moreth, Kristin; Bekeredjian, Raffi; Hrab? de Angelis, Martin; Just, Steffen; Rottbauer, Wolfgang; Eschenhagen, Thomas; Schunkert, Heribert; Carrier, Lucie; Erdmann, Jeanette 
Title:
Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis. 
Abstract:
Cardiomyopathy is one of the most common causes of chronic heart failure worldwide. Mutations in the gene encoding nexilin (NEXN) occur in patients with both hypertrophic and dilated cardiomyopathy (DCM); however, little is known about the pathophysiological mechanisms and relevance of NEXN to these disorders. Here, we evaluated the functional role of NEXN using a constitutive Nexn knock-out (KO) mouse model. Heterozygous (Het) mice were inter-crossed to produce wild-type (WT), Het, and homozyg...    »
 
Journal title abbreviation:
Basic Res Cardiol 
Year:
2016 
Journal volume:
111 
Journal issue:
Pages contribution:
Language:
eng 
Print-ISSN:
0300-8428 
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen