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Document type:
journal article 
Author(s):
Müller, Michaela; Kessler, Thorsten; Schunkert, Heribert; Erdmann, Jeanette; Tennstedt, Stephanie 
Title:
Classification of ADAMTS binding sites: The first step toward selective ADAMTS7 inhibitors. 
Abstract:
Genome-wide association studies identified ADAMTS7 as a risk locus for coronary artery disease. In carotid arteries of rats, neointima formation after balloon-mediated injury goes along with enhanced Adamts7 expression. Vice versa, Adamts7-deficient mice display reduced neointima formation following vascular injury. Although a causal link between ADAMTS7 and coronary artery disease remains to be proven, inhibition of ADAMTS7 represents a potential new target for intervention in this disease. ADA...    »
 
Journal title abbreviation:
Biochem Biophys Res Commun 
Year:
2016 
Journal volume:
471 
Journal issue:
Pages contribution:
380-5 
Language:
eng 
Print-ISSN:
0006-291X 
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen