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Document type:
journal article 
Author(s):
von Heyking, Kristina; Roth, Laura; Ertl, Miriam; Schmidt, Oxana; Calzada-Wack, Julia; Neff, Frauke; Lawlor, Elizabeth R; Burdach, Stefan; Richter, Guenther Hs 
Title:
The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma. 
Abstract:
Microarray analysis revealed genes of the posterior HOXD locus normally involved in bone formation to be over-expressed in primary Ewing sarcoma (ES). The expression of posterior HOXD genes was not influenced via ES pathognomonic EWS/ETS translocations. However, knock down of the dickkopf WNT signaling pathway inhibitor 2 (DKK2) resulted in a significant suppression of HOXD10, HOXD11 and HOXD13 while over-expression of DKK2 and stimulation with factors of the WNT signaling pathway such as WNT3a,...    »
 
Journal title abbreviation:
Oncotarget 
Year:
2016 
Journal volume:
Journal issue:
27 
Pages contribution:
41767-41780 
Language:
eng 
Fulltext / DOI:
TUM Institution:
Kinderklinik und Poliklinik