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Dokumenttyp:
journal article 
Autor(en):
Haas, Tobias; Heidegger, Simon; Wintges, Alexander; Bscheider, Michael; Bek, Sarah; Fischer, Julius C; Eisenkolb, Gabriel; Schmickl, Martina; Spoerl, Silvia; Peschel, Christian; Poeck, Hendrik; Ruland, Jürgen 
Titel:
Card9 controls Dectin-1-induced T-cell cytotoxicity and tumor growth in mice. 
Abstract:
Activation of the C-type lectin receptor Dectin-1 by ?-glucans triggers multiple signals within DCs that result in activation of innate immunity. While these mechanisms can potently prime CD8(+) cytotoxic T-cell (CTL) responses without additional adjuvants, the Dectin-1 effector pathways that control CTL induction remain unclear. Here we demonstrate that Dectin-1-induced CTL cross-priming in mice does not require inflammasome activation but strictly depends on the adapter protein Card9 in vitro....    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2017 
Band / Volume:
47 
Heft / Issue:
Seitenangaben Beitrag:
872-879 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik