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Dokumenttyp:
journal article 
Autor(en):
Düwel, Stephan; Hundshammer, Christian; Gersch, Malte; Feuerecker, Benedikt; Steiger, Katja; Buck, Achim; Walch, Axel; Haase, Axel; Glaser, Steffen J; Schwaiger, Markus; Schilling, Franz 
Titel:
Imaging of pH in vivo using hyperpolarized (13)C-labelled zymonic acid. 
Abstract:
Natural pH regulatory mechanisms can be overruled during several pathologies such as cancer, inflammation and ischaemia, leading to local pH changes in the human body. Here we demonstrate that (13)C-labelled zymonic acid (ZA) can be used as hyperpolarized magnetic resonance pH imaging sensor. ZA is synthesized from [1-(13)C]pyruvic acid and its (13)C resonance frequencies shift up to 3.0 p.p.m. per pH unit in the physiological pH range. The long lifetime of the hyperpolarized signal enhancement...    »
 
Zeitschriftentitel:
Nat Commun 
Jahr:
2017 
Band / Volume:
Seitenangaben Beitrag:
15126 
Sprache:
eng 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie