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Dokumenttyp:
journal article 
Autor(en):
Reitberger, Susanne; Haimerl, Pascal; Aschenbrenner, Isabel; Esser-von Bieren, Julia; Feige, Matthias J 
Titel:
Assembly-induced folding regulates interleukin 12 biogenesis and secretion. 
Abstract:
Members of the IL-12 family perform essential functions in immunoregulation by connecting innate and adaptive immunity and are emerging therapeutic targets. They are unique among other interleukins in forming heterodimers that arise from extensive subunit sharing within the family, leading to the production of at least four functionally distinct heterodimers from only five subunits. This raises important questions about how the assembly of IL-12 family members is regulated and controlled in the...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2017 
Band / Volume:
292 
Heft / Issue:
19 
Seitenangaben Beitrag:
8073-8081 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
Institut für Molekulare Allergologie und Umweltforschung