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Document type:
journal article 
Author(s):
Jung, Bomi; Messias, Ana C; Schorpp, Kenji; Geerlof, Arie; Schneider, Günter; Saur, Dieter; Hadian, Kamyar; Sattler, Michael; Wanker, Erich E; Hasenöder, Stefan; Lickert, Heiko 
Title:
Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation. 
Abstract:
Trafficking of the G protein-coupled receptor (GPCR) Smoothened (Smo) to the primary cilium (PC) is a potential target to inhibit oncogenic Hh pathway activation in a large number of tumors. One drawback is the appearance of Smo mutations that resist drug treatment, which is a common reason for cancer treatment failure. Here, we undertook a high content screen with compounds in preclinical or clinical development and identified ten small molecules that prevent constitutive active mutant SmoM2 tr...    »
 
Journal title abbreviation:
Sci Rep 
Year:
2016 
Journal volume:
Pages contribution:
22540 
Language:
eng 
Fulltext / DOI:
TUM Institution:
II. Medizinische Klinik und Poliklinik