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Dokumenttyp:
journal article 
Autor(en):
Hagemeyer, Nora; Kierdorf, Katrin; Frenzel, Kathrin; Xue, Jia; Ringelhan, Marc; Abdullah, Zeinab; Godin, Isabelle; Wieghofer, Peter; Costa Jordão, Marta Joana; Ulas, Thomas; Yorgancioglu, Gülden; Rosenbauer, Frank; Knolle, Percy A; Heikenwalder, Mathias; Schultze, Joachim L; Prinz, Marco 
Titel:
Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation. 
Abstract:
Recent studies have shown that tissue macrophages (M?) arise from embryonic progenitors of the yolk sac (YS) and fetal liver and colonize tissues before birth. Further studies have proposed that developmentally distinct tissue M? can be identified based on the differential expression of F4/80 and CD11b, but whether a characteristic transcriptional profile exists is largely unknown. Here, we took advantage of an inducible fate-mapping system that facilitated the identification of CD45(+)c-kit(-)C...    »
 
Zeitschriftentitel:
EMBO J 
Jahr:
2016 
Band / Volume:
35 
Heft / Issue:
16 
Seitenangaben Beitrag:
1730-44 
Sprache:
eng 
Print-ISSN:
0261-4189 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik; Institut für Molekulare Immunologie