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Document type:
journal article 
Author(s):
Sala, Luca; Yu, Zhiyi; Ward-van Oostwaard, Dorien; van Veldhoven, Jacobus Pd; Moretti, Alessandra; Laugwitz, Karl-Ludwig; Mummery, Christine L; IJzerman, Adriaan P; Bellin, Milena 
Title:
A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells. 
Abstract:
Long-QT syndrome (LQTS) is an arrhythmogenic disorder characterised by prolongation of the QT interval in the electrocardiogram, which can lead to sudden cardiac death. Pharmacological treatments are far from optimal for congenital forms of LQTS, while the acquired form, often triggered by drugs that (sometimes inadvertently) target the cardiac hERG channel, is still a challenge in drug development because of cardiotoxicity. Current experimental models in vitro fall short in predicting proarrhyt...    »
 
Journal title abbreviation:
EMBO Mol Med 
Year:
2016 
Journal volume:
Journal issue:
Pages contribution:
1065-81 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1757-4676 
TUM Institution:
I. Medizinische Klinik und Poliklinik