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- Document type:
- Journal Article; Article
- Author(s):
- Riedel, J; Straub, L; Wissing, J; Artmann, A; Schmidmayr, M; Kiechle, M; Seifert-Klauss, V R
- Title:
- Vitamin D and Mammographic Findings.
- Abstract:
- Introduction: Pleiotropic immune-modulatory and anti-proliferative effects of vitamin D and hopes to stop cancerogenesis have led to an increased interest in possible reduction of breast cancer with higher vitamin D levels. Mammographic density is an established risk factor for breast cancer risk, and its association with serum vitamin D is complex, as recent studies have shown. Patients and Methods: In this cross-sectional study, 1103 participants were recruited in the breast diagnostic unit of the Klinikum rechts der Isar, TU Munich. A standardised questionnaire and blood samples for 25-OH-vitamin D were taken on the day of mammography. Histologic results of biopsies in suspicious mammographies were documented. Results: In the 1090 data-sets analysed, vitamin D-deficiency was common among women under 40. Highest vitamin D values were observed in participants aged 60-69 years, but average values for all age cohorts were below 20 ng/ml of vitamin D. 15.6 % of all participants had very low vitamin D values (< 10 ng/ml), 51.3 % were vitamin D-deficient (10-19 ng/ml) and only 5.7 % were above 30 ng/ml, i.e. showed sufficient vitamin D. Patients with malignant results had vitamin D < 10 ng/ml more often (16.9 %; p = 0.61), and only 3.4 % in this group had sufficient vitamin D supply (> 30 ng/ml). There were no significant differences in vitamin D-levels between density groups according to the American College of Radiology (ACR) criteria. Conclusion: Vitamin D values were lower than in comparable US women. Up to now, there is no direct clinical evidence for a relationship between the risk for breast cancer and a specific vitamin D value.
- Journal title abbreviation:
- Geburtsh Frauenheilk
- Year:
- 2016
- Journal volume:
- 76
- Journal issue:
- 5
- Pages contribution:
- 570-578
- Language:
- eng
- Fulltext / DOI:
- doi:10.1055/s-0042-106208
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/27239067
- Print-ISSN:
- 0016-5751
- TUM Institution:
- Frauenklinik und Poliklinik
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