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Dokumenttyp:
journal article 
Autor(en):
Vosen, Sarah; Rieck, Sarah; Heidsieck, Alexandra; Mykhaylyk, Olga; Zimmermann, Katrin; Plank, Christian; Gleich, Bernhard; Pfeifer, Alexander; Fleischmann, Bernd K; Wenzel, Daniela 
Titel:
Improvement of vascular function by magnetic nanoparticle-assisted circumferential gene transfer into the native endothelium. 
Abstract:
Gene therapy is a promising approach for chronic disorders that require continuous treatment such as cardiovascular disease. Overexpression of vasoprotective genes has generated encouraging results in animal models, but not in clinical trials. One major problem in humans is the delivery of sufficient amounts of genetic vectors to the endothelium which is impeded by blood flow, whereas prolonged stop-flow conditions impose the risk of ischemia. In the current study we have therefore developed a s...    »
 
Zeitschriftentitel:
J Control Release 
Jahr:
2016 
Band / Volume:
241 
Seitenangaben Beitrag:
164-173 
Sprache:
eng 
Print-ISSN:
0168-3659 
TUM Einrichtung:
Institut für experimentelle Onkologie und Therapieforschung