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Dokumenttyp:
journal article 
Autor(en):
Matzke-Ogi, Alexandra; Jannasch, Katharina; Shatirishvili, Marine; Fuchs, Beatrix; Chiblak, Sara; Morton, Jennifer; Tawk, Bouchra; Lindner, Thomas; Sansom, Owen; Alves, Frauke; Warth, Arne; Schwager, Christian; Mier, Walter; Kleeff, Jörg; Ponta, Helmut; Abdollahi, Amir; Orian-Rousseau, Véronique 
Titel:
Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference With CD44v6 Signaling. 
Abstract:
Cancer cells with high metastatic potential and stem cell-like characteristics express the cell surface marker CD44. CD44 isoforms that include the v6 exon are co-receptors for the receptor tyrosine kinases MET and Vascular Endothelial Growth factor Receptor-2 (VEGFR-2). We studied CD44v6 signaling in several pancreatic cancer cell lines, and its role in tumor growth and metastasis in several models of pancreatic cancer.We analyzed the effects of v6 peptides that interfere with the co-receptor f...    »
 
Zeitschriftentitel:
Gastroenterology 
Jahr:
2016 
Band / Volume:
150 
Heft / Issue:
Seitenangaben Beitrag:
513-25.e10 
Sprache:
eng 
Print-ISSN:
0016-5085 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik