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Document type:
journal article 
Author(s):
Grünwald, Barbara; Harant, Veronika; Schaten, Susanne; Frühschütz, Monika; Spallek, Ria; Höchst, Bastian; Stutzer, Katharina; Berchtold, Sonja; Erkan, Mert; Prokopchuk, Olga; Martignoni, Marc; Esposito, Irene; Heikenwalder, Mathias; Gupta, Aayush; Siveke, Jens; Saftig, Paul; Knolle, Percy; Wohlleber, Dirk; Krüger, Achim 
Title:
Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver. 
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) metastasizes to liver at early stages, making this disease highly lethal. Tissue inhibitor of metalloproteinases-1 (TIMP1) creates a metastasis-susceptible environment in the liver. We investigated the role of TIMP1 and its receptor CD63 in metastasis of early-stage pancreatic tumors using mice and human cell lines and tissue samples.We obtained liver and plasma samples from patients in Germany with chronic pancreatitis, pancreatic intra-epithelial neoplas...    »
 
Journal title abbreviation:
Gastroenterology 
Year:
2016 
Journal volume:
151 
Journal issue:
Pages contribution:
1011-1024.e7 
Language:
eng 
Print-ISSN:
0016-5085 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung; Institut für Molekulare Immunologie; Chirurgiesche Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik