Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Nauerth, Magdalena; Stemberger, Christian; Mohr, Fabian; Weißbrich, Bianca; Schiemann, Matthias; Germeroth, Lothar; Busch, Dirk H 
Titel:
Flow cytometry-based TCR-ligand Koff -rate assay for fast avidity screening of even very small antigen-specific T cell populations ex vivo. 
Abstract:
High epitope-specific sensitivity of CD8(+) T cells is required for optimal immune protection against intracellular pathogens as well as certain malignancies. The quality of antigen recognition of CD8(+) T cells is usually described as "avidity" to its cognate peptide MHCI complex. T cell avidity is mainly dependent on the structural qualities of the T cell receptor (TCR), as convincingly demonstrated by recombinant TCR re-expression experiments. Based on reversible MHCI multimer staining and ko...    »
 
Zeitschriftentitel:
Cytometry A 
Jahr:
2016 
Band / Volume:
89 
Heft / Issue:
Seitenangaben Beitrag:
816-25 
Sprache:
eng 
Print-ISSN:
1552-4922 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene