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Dokumenttyp:
journal article 
Autor(en):
Käbisch, Romy; Semper, Raphaela P; Wüstner, Stefanie; Gerhard, Markus; Mejías-Luque, Raquel 
Titel:
Helicobacter pylori ?-Glutamyltranspeptidase Induces Tolerogenic Human Dendritic Cells by Activation of Glutamate Receptors. 
Abstract:
Helicobacter pylori infection is characterized by chronic persistence of the bacterium. Different virulence factors, including H. pylori ?-glutamyltranspeptidase (gGT), have been reported to induce tolerogenicity by reprogramming dendritic cells (DCs). gGT is present in all bacterial isolates, indicating an important role for gGT in the course of infection. In the current study, we have analyzed the effect of H. pylori gGT on human DCs and the subsequent adaptive immune response. We show that gl...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2016 
Band / Volume:
196 
Heft / Issue:
10 
Seitenangaben Beitrag:
4246-52 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene