Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Cheng, T; Jian, Z; Li, K; Raulefs, S; Regel, I; Shen, S; Zou, X; Ruland, J; Ceyhan, G O; Friess, H; Michalski, C W; Kleeff, J; Kong, B 
Titel:
In vivo functional dissection of a context-dependent role for Hif1? in pancreatic tumorigenesis. 
Abstract:
Hypoxia-inducible factor 1? (Hif1?) is a key regulator of cellular adaptation and survival under hypoxic conditions. In pancreatic ductal adenocarcinoma (PDAC), it has been recently shown that genetic ablation of Hif1? accelerates tumour development by promoting tumour-supportive inflammation in mice, questioning its role as the key downstream target of many oncogenic signals of PDAC. Likely, Hif1? has a context-dependent role in pancreatic tumorigenesis. To further analyse this, murine PDAC cel...    »
 
Zeitschriftentitel:
Oncogenesis 
Jahr:
2016 
Band / Volume:
Heft / Issue:
12 
Seitenangaben Beitrag:
e278 
Sprache:
eng 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; Institut für Klinische Chemie und Pathobiochemie