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Document type:
journal article 
Author(s):
Durek, Pawel; Nordström, Karl; Gasparoni, Gilles; Salhab, Abdulrahman; Kressler, Christopher; de Almeida, Melanie; Bassler, Kevin; Ulas, Thomas; Schmidt, Florian; Xiong, Jieyi; Gla?ar, Petar; Klironomos, Filippos; Sinha, Anupam; Kinkley, Sarah; Yang, Xinyi; Arrigoni, Laura; Amirabad, Azim Dehghani; Ardakani, Fatemeh Behjati; Feuerbach, Lars; Gorka, Oliver; Ebert, Peter; Müller, Fabian; Li, Na; Frischbutter, Stefan; Schlickeiser, Stephan; Cendon, Carla; Fröhler, Sebastian; Felder, Bärbel; Gasparo...    »
 
Title:
Epigenomic Profiling of Human CD4(+) T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development. 
Abstract:
The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. We generated deep epigenomes comprising genome-wide profiles of DNA methylation, histone modifications, DNA accessibility, and coding and non-coding RNA expression in naive, central-, effector-, and terminally differentiated CD45RA(+) CD4(+) Tmem cells from blood and CD69(+) Tmem cells from bone marrow (BM-Tmem). We observed a progressive and proliferation-associated global loss of DNA methylation in het...    »
 
Journal title abbreviation:
Immunity 
Year:
2016 
Journal volume:
45 
Journal issue:
Pages contribution:
1148-1161 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie