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Dokumenttyp:
journal article 
Autor(en):
Fischer, Julius C; Bscheider, Michael; Eisenkolb, Gabriel; Lin, Chia-Ching; Wintges, Alexander; Otten, Vera; Lindemans, Caroline A; Heidegger, Simon; Rudelius, Martina; Monette, Sébastien; Porosnicu Rodriguez, Kori A; Calafiore, Marco; Liebermann, Sophie; Liu, Chen; Lienenklaus, Stefan; Weiss, Siegfried; Kalinke, Ulrich; Ruland, Jürgen; Peschel, Christian; Shono, Yusuke; Docampo, Melissa; Velardi, Enrico; Jenq, Robert R; Hanash, Alan M; Dudakov, Jarrod A; Haas, Tobias; van den Brink, Marcel R M;...    »
 
Titel:
RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury. 
Abstract:
The molecular pathways that regulate the tissue repair function of type I interferon (IFN-I) during acute tissue damage are poorly understood. We describe a protective role for IFN-I and the RIG-I/MAVS signaling pathway during acute tissue damage in mice. Mice lacking mitochondrial antiviral-signaling protein (MAVS) were more sensitive to total body irradiation- and chemotherapy-induced intestinal barrier damage. These mice developed worse graft-versus-host disease (GVHD) in a preclinical model...    »
 
Zeitschriftentitel:
Sci Transl Med 
Jahr:
2017 
Band / Volume:
Heft / Issue:
386 
Sprache:
eng 
Print-ISSN:
1946-6234 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik