Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Schreck, Christina; Istvánffy, Rouzanna; Ziegenhain, Christoph; Sippenauer, Theresa; Ruf, Franziska; Henkel, Lynette; Gärtner, Florian; Vieth, Beate; Florian, M Carolina; Mende, Nicole; Taubenberger, Anna; Prendergast, Áine; Wagner, Alina; Pagel, Charlotta; Grziwok, Sandra; Götze, Katharina S; Guck, Jochen; Dean, Douglas C; Massberg, Steffen; Essers, Marieke; Waskow, Claudia; Geiger, Hartmut; Schiemann, Mathias; Peschel, Christian; Enard, Wolfgang; Oostendorp, Robert A J 
Titel:
Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells. 
Abstract:
Here, we show that the Wnt5a-haploinsufficient niche regenerates dysfunctional HSCs, which do not successfully engraft in secondary recipients. RNA sequencing of the regenerated donor Lin(-) SCA-1(+) KIT(+) (LSK) cells shows dysregulated expression of ZEB1-associated genes involved in the small GTPase-dependent actin polymerization pathway. Misexpression of DOCK2, WAVE2, and activation of CDC42 results in apolar F-actin localization, leading to defects in adhesion, migration and homing of HSCs r...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2017 
Band / Volume:
214 
Heft / Issue:
Seitenangaben Beitrag:
165-181 
Sprache:
eng 
Print-ISSN:
0022-1007 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene