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Dokumenttyp:
journal article 
Autor(en):
Tong, Jenny; Davis, Harold W; Summer, Suzanne; Benoit, Stephen C; Haque, Ahrar; Bidlingmaier, Martin; Tschöp, Matthias H; D'Alessio, David 
Titel:
Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans. 
Abstract:
Unacylated ghrelin (UAG) is the predominant ghrelin isoform in the circulation. Despite its inability to activate the classical ghrelin receptor, preclinical studies suggest that UAG may promote ?-cell function. We hypothesized that UAG would oppose the effects of acylated ghrelin (AG) on insulin secretion and glucose tolerance. AG (1 µg/kg/h), UAG (4 µg/kg/h), combined AG+UAG, or saline were infused to 17 healthy subjects (9 men and 8 women) on four occasions in randomized order. Ghrelin was in...    »
 
Zeitschriftentitel:
Diabetes 
Jahr:
2014 
Band / Volume:
63 
Heft / Issue:
Seitenangaben Beitrag:
2309-19 
Sprache:
eng 
Print-ISSN:
0012-1797 
TUM Einrichtung:
Fakultät für Medizin (zentral angehängte Professuren und Einrichtungen: Profs. Tschöp, Berberat; TUMCells, ZPF, MSZ)