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- Dokumenttyp:
- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
- Autor(en):
- Kim, Jae Geun; Suyama, Shigetomo; Koch, Marco; Jin, Sungho; Argente-Arizon, Pilar; Argente, Jesús; Liu, Zhong-Wu; Zimmer, Marcelo R; Jeong, Jin Kwon; Szigeti-Buck, Klara; Gao, Yuanqing; García-Cáceres, Cristina; Yi, Chun-Xia; Salmaso, Natalina; Vaccarino, Flora M; Chowen, Julie; Diano, Sabrina; Dietrich, Marcelo O; Tschöp, Matthias H; Horvath, Tamas L
- Titel:
- Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding.
- Abstract:
- We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by lept... »
- Zeitschriftentitel:
- Nat Neurosci
- Jahr:
- 2014
- Band / Volume:
- 17
- Heft / Issue:
- 7
- Seitenangaben Beitrag:
- 908-10
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1038/nn.3725
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/24880214
- Print-ISSN:
- 1097-6256
- TUM Einrichtung:
- Kliniken und Institute
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