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Dokumenttyp:
journal article 
Autor(en):
Keuper, Michaela; Jastroch, Martin; Yi, Chun-Xia; Fischer-Posovszky, Pamela; Wabitsch, Martin; Tschöp, Matthias H; Hofmann, Susanna M 
Titel:
Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions. 
Abstract:
Mitochondrial dysfunction in white adipose tissue plays a key role in the pathogenesis of type 2 diabetes. Emerging evidence specifically suggests that altered oxidative phosphorylation in adipocytes may have a relevant effect on systemic glucose homeostasis, requiring understanding of adipocyte bioenergetics. We analyzed energetic flux of an intact human adipocyte cell model by plate-based respirometry and extracellular acidification. During differentiation, we discovered that glycolytic ATP pr...    »
 
Zeitschriftentitel:
FASEB J 
Jahr:
2014 
Band / Volume:
28 
Heft / Issue:
Seitenangaben Beitrag:
761-70 
Sprache:
eng 
Print-ISSN:
0892-6638 
TUM Einrichtung:
Fakultät für Medizin (zentral angehängte Professuren und Einrichtungen: Profs. Tschöp, Berberat; TUMCells, ZPF, MSZ)