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Document type:
journal article 
Author(s):
Clemmensen, Christoffer; Chabenne, Joseph; Finan, Brian; Sullivan, Lorraine; Fischer, Katrin; Küchler, Daniela; Sehrer, Laura; Ograjsek, Teja; Hofmann, Susanna M; Schriever, Sonja C; Pfluger, Paul T; Pinkstaff, Jason; Tschöp, Matthias H; Dimarchi, Richard; Müller, Timo D 
Title:
GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet. 
Abstract:
We recently reported restoration of leptin responsiveness in diet-induced obese (DIO) mice using a pharmacologically optimized, polyethylene-glycolated (PEG)-leptin analog in combination with exendin-4 or FGF21. However, the return of leptin action required discontinuation of high-fat diet (HFD) exposure. Here we assess whether a single peptide possessing balanced coagonism at the glucagon-like peptide 1 (GLP-1) and glucagon receptors can restore leptin responsiveness in DIO mice maintained on a...    »
 
Journal title abbreviation:
Diabetes 
Year:
2014 
Journal volume:
63 
Journal issue:
Pages contribution:
1422-7 
Language:
eng 
Print-ISSN:
0012-1797 
TUM Institution:
Fakultät für Medizin (zentral angehängte Professuren und Einrichtungen: Profs. Tschöp, Berberat; TUMCells, ZPF, MSZ)