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Document type:
journal article 
Author(s):
Stevanovic, Darko; Trajkovic, Vladimir; Müller-Lühlhoff, Sabrina; Brandt, Elisabeth; Abplanalp, William; Bumke-Vogt, Christiane; Liehl, Beate; Wiedmer, Petra; Janjetovic, Kristina; Starcevic, Vesna; Pfeiffer, Andreas F H; Al-Hasani, Hadi; Tschöp, Matthias H; Castañeda, Tamara R 
Title:
Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling. 
Abstract:
Signaling through the mammalian target of rapamycin complex 1 (mTORC1) and its effectors the S6-kinases (S6K) in the hypothalamus is thought to be involved in nutrient sensing and control of food intake. Given the anatomical proximity of this pathway to circuits for the hormone ghrelin, we investigated the potential role of the mTORC1/S6K pathway in mediating the metabolic effects of ghrelin. We found that ghrelin promoted phosphorylation of S6K1 in the mouse hypothalamic cell line N-41 and in t...    »
 
Journal title abbreviation:
Mol Cell Endocrinol 
Year:
2013 
Journal volume:
381 
Journal issue:
1-2 
Pages contribution:
280-90 
Language:
eng 
Print-ISSN:
0303-7207 
TUM Institution:
Fakultät für Medizin (zentral angehängte Professuren und Einrichtungen: Profs. Tschöp, Berberat; TUMCells, ZPF, MSZ)