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Document type:
journal article 
Author(s):
Dinter, Juliane; Mühlhaus, Jessica; Wienchol, Carolin Leonie; Yi, Chun-Xia; Nürnberg, Daniela; Morin, Silke; Grüters, Annette; Köhrle, Josef; Schöneberg, Torsten; Tschöp, Matthias; Krude, Heiko; Kleinau, Gunnar; Biebermann, Heike 
Title:
Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5. 
Abstract:
Application of 3-iodothyronamine (3-T1AM) results in decreased body temperature and body weight in rodents. The trace amine-associated receptor (TAAR) 1, a family A G protein-coupled receptor, is a target of 3-T1AM. However, 3-T1AM effects still persist in mTaar1 knockout mice, which suggest so far unknown further receptor targets that are of physiological relevance. TAAR5 is a highly conserved TAAR subtype among mammals and we here tested TAAR5 as a potential 3-T1AM target. First, we investigat...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2015 
Journal volume:
10 
Journal issue:
Pages contribution:
e0117774 
Language:
eng 
TUM Institution:
Fakultät für Medizin (zentral angehängte Professuren und Einrichtungen: Profs. Tschöp, Berberat; TUMCells, ZPF, MSZ)