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Document type:
journal article 
Author(s):
Reis, Wagner L; Yi, Chun-Xia; Gao, Yuanqing; Tschöp, Mathias H; Stern, Javier E 
Title:
Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior. 
Abstract:
Hypothalamic inflammation, involving microglia activation in the arcuate nucleus (ARC), is proposed as a novel underlying mechanism in obesity, insulin and leptin resistance. However, whether activated microglia affects ARC neuronal activity, and consequently basal and hormonal-induced food intake, is unknown. We show that lipopolysaccharide, an agonist of the toll-like receptor-4 (TLR4), which we found to be expressed in ARC microglia, inhibited the firing activity of the majority of orexigenic...    »
 
Journal title abbreviation:
Endocrinology 
Year:
2015 
Journal volume:
156 
Journal issue:
Pages contribution:
1303-15 
Language:
eng 
Print-ISSN:
0013-7227 
TUM Institution:
Fakultät für Medizin (zentral angehängte Professuren und Einrichtungen: Profs. Tschöp, Berberat; TUMCells, ZPF, MSZ)