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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Aschenbrenner, M.; Kulozik, U.; Först, P. 
Titel:
Evaluation of the relevance of the glassy state as stability criterion for freeze-dried bacteria by application of the Arrhenius and WLF model // Evaluation of the relevance of the glassy state as stability criterion for freeze-dried bacteria by application of the Arrhenius and WLF model 
Abstract:
The aim of this work was to describe the temperature dependence of microbial inactivation for several storage conditions and protective systems (lactose, trehalose and dextran) in relation to the physical state of the sample, i.e. the glassy or non-glassy state. The resulting inactivation rates k were described by applying two models, Arrhenius and Williams--Landel--Ferry (WLF), in order to evaluate the relevance of diffusional limitation as a protective mechanism. The application of the Arrheni...    »
 
Stichworte:
Freeze-drying; Bacteria; Glassy state; Storage stability; restriced diffusion; Arrhenius; WLF 
Zeitschriftentitel:
Cryobiology 
Jahr:
2012 
Band / Volume:
65 
Heft / Issue:
65 // 3 
Seitenangaben Beitrag:
308--318