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Dokumenttyp:
journal article 
Autor(en):
Mei, Feng; Lehmann-Horn, Klaus; Shen, Yun-An A; Rankin, Kelsey A; Stebbins, Karin J; Lorrain, Daniel S; Pekarek, Kara; A Sagan, Sharon; Xiao, Lan; Teuscher, Cory; von Büdingen, H-Christian; Wess, Jürgen; Lawrence, J Josh; Green, Ari J; Fancy, Stephen Pj; Zamvil, Scott S; Chan, Jonah R 
Titel:
Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery. 
Abstract:
Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss. Inflammatory demyelination is accompanied by significant neuronal loss in the experimental autoimmune encephalomyelitis (EAE) mouse model and evidence for remyelination in this model is complicated by ongoing inflammation, degeneration and possible remyelination. Demonstrating the functional sign...    »
 
Zeitschriftentitel:
Elife 
Jahr:
2016 
Band / Volume:
Sprache:
eng 
TUM Einrichtung:
Neurologische Klinik und Poliklinik