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Dokumenttyp:
journal article 
Autor(en):
Lehmann-Horn, Klaus; Wang, Sheng-Zhi; Sagan, Sharon A; Zamvil, Scott S; von Büdingen, H-Christian 
Titel:
B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue. 
Abstract:
Ectopic lymphoid tissues (ELT) can be found in multiple sclerosis (MS) and other organ-specific inflammatory conditions. Whether ELT in the meninges of central nervous system (CNS) autoimmune disease exhibit local germinal center (GC) activity remains unknown. In an experimental autoimmune encephalomyelitis model of CNS autoimmunity, we found activation-induced cytidine deaminase, a GC-defining enzyme, in meningeal ELT (mELT) densely populated by B and T cells. To determine GC activity in mELT,...    »
 
Zeitschriftentitel:
JCI Insight 
Jahr:
2016 
Band / Volume:
Heft / Issue:
20 
Seitenangaben Beitrag:
e87234 
Sprache:
eng 
Print-ISSN:
TUM Einrichtung:
Neurologische Klinik und Poliklinik