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Document type:
journal article 
Author(s):
Horsman, Michael R; Vaupel, Peter 
Title:
Pathophysiological Basis for the Formation of the Tumor Microenvironment. 
Abstract:
Poor microenvironmental conditions are a characteristic feature of solid tumors. Such conditions occur because the tumor vascular supply, which develops from the normal host vasculature by the process of angiogenesis, is generally inadequate in meeting the oxygen and nutrient demands of the growing tumor mass. Regions of low oxygenation (hypoxia) is believed to be the most critical deficiency, since it has been well documented to play a significant role in influencing the response to conventiona...    »
 
Journal title abbreviation:
Front Oncol 
Year:
2016 
Journal volume:
Pages contribution:
66 
Language:
eng 
Fulltext / DOI:
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie