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- Document type:
- Journal Article; Editorial Material
- Author(s):
- Lehmann-Horn, Klaus; Penkert, Horst; Grein, Peter; Leppmeier, Ulrich; Teuber-Hanselmann, Sarah; Hemmer, Bernhard; Berthele, Achim
- Title:
- PML during dimethyl fumarate treatment of multiple sclerosis: How does lymphopenia matter?
- Abstract:
- Progressive multifocal leukoencephalopathy (PML), which is caused by the John Cunningham virus (JCV), is a rare brain disease that results in persistent neurologic disability or death. In multiple sclerosis (MS), PML is a major concern in patients treated with natalizumab, and treatment duration (more than 2 years), preceding immunosuppression, and JCV antibody serostatus are identified risk factors, which are used for risk stratification, patient monitoring, and counseling.
- Journal title abbreviation:
- Neurology
- Year:
- 2016
- Journal volume:
- 87
- Journal issue:
- 4
- Pages contribution:
- 440-1
- Language:
- eng
- Fulltext / DOI:
- doi:10.1212/WNL.0000000000002900
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/27343070
- Print-ISSN:
- 0028-3878
- TUM Institution:
- Neurologische Klinik und Poliklinik
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