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Dokumenttyp:
journal article 
Autor(en):
Bisht, Savita; Schlesinger, Martin; Rupp, Alexander; Schubert, Rolf; Nolting, Jens; Wenzel, Jörg; Holdenrieder, Stefan; Brossart, Peter; Bendas, Gerd; Feldmann, Georg 
Titel:
A liposomal formulation of the synthetic curcumin analog EF24 (Lipo-EF24) inhibits pancreatic cancer progression: towards future combination therapies. 
Abstract:
Pancreatic cancer is one of the most lethal of human malignancies known to date and shows relative insensitivity towards most of the clinically available therapy regimens. 3,5-bis(2-fluorobenzylidene)-4-piperidone (EF24), a novel synthetic curcumin analog, has shown promising in vitro therapeutic efficacy in various human cancer cells, but insufficient water solubility and systemic bioavailability limit its clinical application. Here, we describe nano-encapsulation of EF24 into pegylated liposom...    »
 
Zeitschriftentitel:
J Nanobiotechnology 
Jahr:
2016 
Band / Volume:
14 
Heft / Issue:
Seitenangaben Beitrag:
57 
Sprache:
eng 
TUM Einrichtung:
Institut für Laboratoriumsmedizin