User: Guest  Login
Document type:
journal article 
Author(s):
Ehling, Petra; Meuth, Patrick; Eichinger, Paul; Herrmann, Alexander M; Bittner, Stefan; Pawlowski, Matthias; Pankratz, Susann; Herty, Michael; Budde, Thomas; Meuth, Sven G 
Title:
Human T cells in silico: Modelling their electrophysiological behaviour in health and disease. 
Abstract:
Although various types of ion channels are known to have an impact on human T cell effector functions, their exact mechanisms of influence are still poorly understood. The patch clamp technique is a well-established method for the investigation of ion channels in neurons and T cells. However, small cell sizes and limited selectivity of pharmacological blockers restrict the value of this experimental approach. Building a realistic T cell computer model therefore can help to overcome these kinds o...    »
 
Journal title abbreviation:
J Theor Biol 
Year:
2016 
Journal volume:
404 
Pages contribution:
236-50 
Language:
eng 
Print-ISSN:
0022-5193 
TUM Institution:
Abteilung für Neuroradiologie