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Dokumenttyp:
journal article 
Autor(en):
Gröschel, Stefan; Bommer, Martin; Hutter, Barbara; Budczies, Jan; Bonekamp, David; Heining, Christoph; Horak, Peter; Fröhlich, Martina; Uhrig, Sebastian; Hübschmann, Daniel; Geörg, Christina; Richter, Daniela; Pfarr, Nicole; Pfütze, Katrin; Wolf, Stephan; Schirmacher, Peter; Jäger, Dirk; von Kalle, Christof; Brors, Benedikt; Glimm, Hanno; Weichert, Wilko; Stenzinger, Albrecht; Fröhling, Stefan 
Titel:
Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification. 
Abstract:
Identification of the tissue of origin in cancer of unknown primary (CUP) poses a diagnostic challenge and is critical for directing site-specific therapy. Currently, clinical decision-making in patients with CUP primarily relies on histopathology and clinical features. Comprehensive molecular profiling has the potential to contribute to diagnostic categorization and, most importantly, guide CUP therapy through identification of actionable lesions. We here report the case of an advanced-stage ma...    »
 
Zeitschriftentitel:
Cold Spring Harb Mol Case Stud 
Jahr:
2016 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
a001180 
Sprache:
eng 
Print-ISSN:
2373-2865 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie