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Document type:
Zeitschriftenaufsatz 
Author(s):
Somoza, Veronika; Lindenmeier, Michael; Wenzel, Elisabeth; Frank, Oliver; Erbersdobler, Helmut F.; Hofmann, Thomas 
Title:
Activity-guided identification of a chemopreventive compound in coffee beverage using in vitro and in vivo techniques 
Abstract:
The aim of the present study was to apply an activity-guided screening procedure to coffee brew to identify a key chemopreventive compound by means of in vitro antioxidant tests as well as cell culture experiments and to prove the in vivo activity of that compound by an animal feeding experiment. Solvent fractionation, followed by multiple-step ultrafiltration, revealed that the polar coffee compounds with molecular weights below 1 kDa show the major inhibitory effect on the in vitro peroxidatio...    »
 
Journal title:
Journal of Agricultural and Food Chemistry 
Year:
2003 
Journal volume:
51 
Journal issue:
23 
Pages contribution:
6861--6869 
Fulltext / DOI:
Print-ISSN:
0021-8561