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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Marxen, Sandra; Stark, Timo D.; Rütschle, Andrea; Lücking, Genia; Frenzel, Elrike; Scherer, Siegfried; Ehling-Schulz, Monika; Hofmann, Thomas 
Titel:
Depsipeptide Intermediates Interrogate Proposed Biosynthesis of Cereulide, the Emetic Toxin of Bacillus cereus 
Abstract:
Cereulide and isocereulides A-G are biosynthesized as emetic toxins by Bacillus cereus via a non-ribosomal peptide synthetase (NRPS) called Ces. Although a thiotemplate mechanisms involving cyclo-trimerization of ready-made D-O-Leu-D-Ala-L-O-Val-L-Val via a thioesterase (TE) domain is proposed for cereulide biosynthesis, the exact mechanism is far from being understood. UPLC-TOF MS analysis of B. cereus strains in combination with (13)C-labeling experiments now revealed tetra-, octa-, and dodeca...    »
 
Zeitschriftentitel:
Scientific reports 
Jahr:
2015 
Band / Volume:
Seitenangaben Beitrag:
10637 
Print-ISSN:
2045-2322