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Dokumenttyp:
journal article 
Autor(en):
Schulz, Dominik; Wirth, Markus; Piontek, Guido; Buchberger, Anna Maria Stefanie; Schlegel, Jürgen; Reiter, Rudolf; Multhoff, Gabriele; Pickhard, Anja 
Titel:
HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances. 
Abstract:
Despite remarkable successes with targeted therapies in the treatment of cancer, resistance can occur which limits the clinical outcome. In this study, we generated and characterized resistant cell clones derived from two different head and neck squamous cell carcinoma (HNSCC) cell lines (Cal27, UD-SCC-5) by long-term exposure to five targeted- and chemotherapeutics (afatinib, MK2206, BEZ235, olaparib and cisplatin). The resistant tumor cell clones showed an increased ERK1/2 expression and an al...    »
 
Zeitschriftentitel:
Am J Cancer Res 
Jahr:
2016 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
1963-1975 
Sprache:
eng 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie